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Ligand interaction of sustituted pyridines with cytochrome P-450

J L Born, S Early

Journal of Pharmaceutical Sciences

|July 1, 1980

Abstract:

A series of pyridyl ketones and alkyl pyridines was evaluated as type II ligands for cytochrome P-450. Activity as type II ligands was evaluated in terms of the lipid solubility and the pKa values of the compounds.

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