Related Experiment Video

Updated: Aug 8, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Atypical measles in adolescent siblings 16 years after killed measles virus vaccine

V A Fulginiti, R E Helfer

    JAMA
    |August 22, 1980
    PubMed

    Insights

    A long-term study of four siblings revealed that atypical measles developed 16 years after receiving the killed measles vaccine, even with later live vaccine doses. This highlights potential long-term risks associated with early measles vaccination strategies.

    Area of Science:

    • Immunology
    • Vaccinology
    • Pediatric Infectious Diseases

    Background:

    • Measles vaccination history is crucial for understanding long-term immunity.
    • Previous measles vaccines included inactivated (killed) and live-attenuated forms.
    • Atypical measles presentation can occur years after vaccination or exposure.

    Purpose of the Study:

    • To detail the long-term outcomes of measles vaccine administration and natural disease exposure.
    • To investigate the development of atypical measles in relation to vaccination history.

    Main Methods:

    • Longitudinal case study over 16 years.
    • Detailed records of killed and live measles vaccine administration.
    • Documentation of exposure to natural measles disease.
    • Clinical observation of measles development in four adolescent siblings.

    Main Results:

    • Atypical measles developed in two siblings 16 years post-killed measles vaccine administration.
    • This occurred despite subsequent live measles virus vaccine doses in the affected siblings.
    • The study tracked vaccine history and disease progression over a significant period.

    Conclusions:

    • The killed measles virus vaccine may be associated with the later development of atypical measles.
    • Subsequent live measles vaccine doses did not prevent atypical measles in this context.
    • This case series underscores the importance of vaccine formulation and long-term surveillance.

    More Related Videos

    Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis08:44

    Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

    Published on: September 7, 2022

    Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique09:37

    Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique

    Published on: September 23, 2022

    Related Concept Videos

    Vaccinations01:51

    Vaccinations

    Overview
    Diphtheria01:28

    Diphtheria

    Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
    Atypical Pneumonia01:14

    Atypical Pneumonia

    Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
    Chickenpox01:20

    Chickenpox

    Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
    Poliomyelitis01:17

    Poliomyelitis

    Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
    Respiratory Syncytial Virus Disease01:29

    Respiratory Syncytial Virus Disease

    Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...