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[Ultrastructure of the contractile myocardium in chronic ischemic heart disease]

G D Kniazeva, M D Kniazev, G F Sheremet'eva

    Kardiologiia
    |May 1, 1980
    PubMed

    Insights

    Chronic ischemic heart disease causes severe cell damage in the heart's left ventricle. These ultrastructural changes, including dystrophy and some regeneration, may lead to cardiac insufficiency.

    Area of Science:

    • Cardiovascular Biology
    • Cellular Pathology

    Context:

    • Chronic ischemic heart disease (CIHD) affects myocardial contractility.
    • Left ventricular myocardium is crucial for cardiac function.

    Purpose:

    • To investigate the ultrastructural changes in the contractile myocardium of the left ventricle in patients with CIHD.
    • To correlate these changes with the development of cardiac insufficiency.

    Summary:

    • Ultrastructural analysis of 24 myocardial biopsies revealed significant dystrophic alterations in myocyte organelles and myofibrils.
    • These changes are attributed to progressive ischemia.
    • Evidence of intracellular regeneration, including euchromatin and increased RNA granules, was also observed in some myocytes.

    Impact:

    • The study highlights the detrimental impact of chronic ischemia on myocardial ultrastructure.
    • Prevalence of dystrophic changes may contribute to cardiac insufficiency in CIHD patients.
    • Findings provide insights into cellular mechanisms underlying heart failure in ischemic heart disease.

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