Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aborting solid tumours: a possible role for PGF2alpha

R D Pearson

    Medical Hypotheses
    |February 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Prostaglandin F2alpha (PGF2alpha), known for its role in childbirth, may also activate macrophages to destroy tumor cells. This suggests PGF2alpha could potentially

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Comparative analyses of whole genome sequences of Leishmania infantum isolates from humans and dogs in northeastern Brazil.

    International journal for parasitology·2017
    Same author

    The emergence of concurrent HIV-1/AIDS and visceral leishmaniasis in Northeast Brazil.

    Transactions of the Royal Society of Tropical Medicine and Hygiene·2011
    Same author

    Atypical American visceral leishmaniasis caused by disseminated Leishmania amazonensis infection presenting with hepatitis and adenopathy.

    Transactions of the Royal Society of Tropical Medicine and Hygiene·2005
    Same author

    Distribution of phlebotomine sand flies (Diptera: Psychodidae) in the state of Rio Grande do Norte, Brazil.

    Journal of medical entomology·2004
    Same author

    Identification and molecular characterisation of a peritrophin gene, peritrophin-48, from the myiasis fly Chrysomya bezziana.

    Insect biochemistry and molecular biology·2001
    Same author

    Cerebral malaria and developmental biology: making parasites grow-up.

    Medical hypotheses·2001
    Same journal

    Calcitonin Gene-Related Peptide-Induced Central Sensitization: A Hypothesis for Long COVID Symptoms.

    Medical hypotheses·2026
    Same journal

    Subclinical mastitis during lactation: a modifiable risk factor for breast cancer?

    Medical hypotheses·2025
    Same journal

    The Role of Hemispheric Sensory Shifts: Impacts on Stretch Reflex and Motor Plasticity Post-Stroke.

    Medical hypotheses·2025
    Same journal

    Neuron-Targeted Exosome Therapy: A Novel Approach for Treating Cardiogenic Dementia via RyR2 Inhibition.

    Medical hypotheses·2025
    Same journal

    How the Somatosensory System Adapts to the Motor Change in Stroke: A Hemispheric Shift?

    Medical hypotheses·2024
    Same journal

    Unstable Plaque is a Treatable Cause of Cognitive Decline.

    Medical hypotheses·2024
    See all related articles

    Area of Science:

    • Immunology
    • Reproductive Biology
    • Oncology

    Background:

    • Prostaglandin F2alpha (PGF2alpha) is an endogenous mediator of parturition.
    • PGF2alpha is also recognized as an effective abortifacient agent.

    Purpose of the Study:

    • To investigate the hypothesis that PGF2alpha can activate macrophages for tumoricidal activity.
    • To explore the potential of PGF2alpha in 'aborting' tumor cell mass.

    Main Methods:

    • Review and presentation of indirect evidence supporting the proposed mechanism.
    • Theoretical exploration of the mode of action for PGF2alpha as a macrophage activator.

    Main Results:

    • Indirect evidence suggests PGF2alpha may activate macrophages against tumor cells.

    Related Experiment Videos

  • A theoretical framework for this proposed mechanism is presented.

    • Conclusions:

    • PGF2alpha exhibits potential as a macrophage tumoricidal activator.
    • Further research is warranted to validate the direct anti-tumor effects of PGF2alpha.