Mixed connective tissue disease with associated glomerulonephritis and hypocomplementaemia

Area of Science:

• Rheumatology
• Nephrology
• Immunology

Background:

• Mixed connective tissue disease (MCTD) is a complex autoimmune disorder.
• Renal involvement and hypocomplementaemia are considered uncommon in MCTD.

Observation:

• A patient presented with features of MCTD, including unusual renal disease.
• The patient also exhibited hypocomplementaemia, a rare associated finding.

Findings:

• The systemic sclerosis component of MCTD responded well to corticosteroid therapy.
• A family history of other connective tissue diseases was noted in the patient.

Implications:

• This case expands the understanding of potential renal manifestations in MCTD.
• It underscores the importance of considering hypocomplementaemia in MCTD patients with renal issues.
• The findings suggest a potential genetic predisposition to connective tissue diseases within families.