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Morphine selectively influences macronutrient intake in the rat

R Marks-Kaufman, R B Kanarek

    Pharmacology, Biochemistry, and Behavior
    |March 1, 1980
    PubMed
    Summary

    Morphine administration suppressed macronutrient intake in rats dose-dependently. While protein and carbohydrate intake remained low, fat intake increased overall, indicating a shift in dietary self-selection.

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    Area of Science:

    • Neuroscience
    • Behavioral Neuroscience
    • Nutritional Neuroscience

    Background:

    • Opioid drugs like morphine can affect feeding behavior.
    • Understanding how morphine influences macronutrient selection is crucial for managing its side effects.

    Purpose of the Study:

    • To investigate the effects of different morphine sulphate doses on the dietary self-selection of protein, carbohydrate, and fat in male rats.
    • To determine the dose-dependency and temporal patterns of morphine's impact on macronutrient intake.

    Main Methods:

    • Male rats were administered three doses of morphine sulphate (10 mg, 15 mg, and 30 mg/kg body weight).
    • Dietary self-selection of protein, carbohydrate, and fat was monitored over a six-hour period post-administration.

    Main Results:

    • Morphine administration suppressed the intake of all three macronutrients in a dose-dependent manner within the initial two hours.
    • Protein and carbohydrate intake remained suppressed for the entire six-hour feeding period.
    • Fat intake, initially suppressed, showed a rebound increase during the final four hours, leading to a net overall increase.

    Conclusions:

    • Morphine sulphate significantly alters macronutrient self-selection in rats.
    • The drug induces a dose-dependent suppression of intake, with a notable compensatory increase in fat consumption over time.

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