Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

d-Amphetamine, operant history, and variable-interval performance

A Poling, K Krafft, L Chapman

    Pharmacology, Biochemistry, and Behavior
    |April 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Laser beam pointing stabilization using analog position-sensitive diodes.

    The Review of scientific instruments·2025
    Same author

    Profound Vagal Tone and Bradycardia Mimicking Asystole: A Resuscitation Case Report.

    Case reports in cardiology·2022
    Same author

    Electronic Vetting of Imaging Requests: Increasing Productivity and Patient Safety.

    Irish medical journal·2020
    Same author

    Expression of BrpA in Streptococcus mutans is regulated by FNR-box mediated repression.

    Molecular oral microbiology·2017
    Same author

    A systematic quality assessment of Environmental Impact Statements in the oil and gas industry.

    The Science of the total environment·2016
    Same author

    Concurrent schedule performance in domestic goats: persistent undermatching.

    Behavioural processes·2014
    Same journal

    Chronic psilocin microdosing produces limited behavioral effects and does not enhance neurogenesis in rats.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Modulation of prefrontal NMDA receptors reveals pharmacogenetic differences between SHR and SLA16 rat strains.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Spontaneous oxycodone withdrawal alters behavior and oligodendrocyte-related gene expression in mice.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Improvement in depressive symptoms in people undergoing cognitive behavioral therapy who supplemented with probiotics: An open-label, pilot study.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Long-term follow-up of children with autism spectrum disorder and severe treatment-resistant behavioral symptoms treated with purified cannabidiol.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Fluoxetine reduces anxiety-like behavior but increases motor impairments in the early stages of a progressive model of Parkinson's disease.

    Pharmacology, biochemistry, and behavior·2026
    See all related articles

    Operant history had minimal impact on how rats responded to d-amphetamine. Drug effects were similar across different rat groups, suggesting current conditions, not past training, primarily influence behavior under these experimental settings.

    Area of Science:

    • Behavioral Neuroscience
    • Psychopharmacology
    • Animal Behavior

    Background:

    • Operant conditioning shapes behavior through reinforcement schedules.
    • Drug effects can be influenced by an organism's prior behavioral history.
    • Understanding these interactions is crucial for behavioral pharmacology.

    Purpose of the Study:

    • To investigate the influence of distinct operant histories on the effects of d-amphetamine.
    • To determine if prior training schedules alter behavioral responses to stimulant drugs.
    • To examine the interplay between behavioral history and current environmental contingencies.

    Main Methods:

    • Rats were trained under either a fixed-ratio (FR20) or an interresponse-time-greater-than-12-sec (IRT>12s) schedule.
    • Subsequently, both groups were exposed to a variable-interval (VI60) schedule until response rates stabilized.

    Related Experiment Videos

  • The effects of acute d-amphetamine sulfate administration (0.25-2.0 mg/kg) on bar-pressing behavior were then assessed.

    • Main Results:

    • Initial operant histories led to vastly different response rates (FR20 > IRT>12s).
    • Response rates converged under the VI60 schedule, indicating adaptation to current reinforcement conditions.
    • D-amphetamine produced dose-dependent decreases in bar-pressing rates for both groups, with similar effects observed.

    Conclusions:

    • The influence of operant history on d-amphetamine's effects was limited under the VI60 schedule.
    • Current environmental contingencies (the VI60 schedule) exerted strong control over behavior, overshadowing historical effects.
    • The findings suggest that behavioral history is a less significant factor when current conditions strongly dictate behavior.