Blockade of audiogenic seizures by bromocryptine

In 21-day-old DBA/2H mice, bromocryptine (5 mgKg-1) induces great reduction of total and lethal audiogenic seizures. This effect increases with time during the first hour after injection. In mice pretreated with spiroperidol (0.5 mgKg-1), bromocryptine fails to produce this protective effect. These results suggest that dopaminergic pathways may be involved in inhibition of audiogenic seizures.