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Updated: Aug 13, 2026

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
Published on: January 14, 2014
[Malignant thyroid neoplasms at the Geneva Institute of Pathology from 1967-1976]
Abstract:
A survey of all malignant thyroid tumors observed during a ten-year period (1967-1976) in Geneva showed a 8.8% incidence (= 197 cases) of malignancies among surgically removed thyroids and a 0.38% incidence (= 43 cases) at autopsy. In the surgical material, 85% of the tumors were well differentiated carcinomas, while in the post mortem series, only 44% were of the organoid variety, the predominating tumor in this group being the anaplastic carcinoma. These data are comparable to those found in Basel and in Zurich. While the incidence of malignant thyroid tumors seems to remian constant in Switzerland, there is a shift from follicular towards papillary carcinomas within the group of organoid tumors. This change has gradually taken place during the last three to four decades; it has been observed in all three centers and is related, by the author, to the introduction of iodide to kitchen salt in Switzerland.
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