[Drug induced fluorosis in myeloma]

Osteolytic lesions of bone in multiple myeloma may be treated by florides. A patient is reported who had IgA-Myeloma, was treated with high doses of sodium floride for 16 months and developed the clinical and radiological picture of advanced fluorosis. Within one year after discontinuing sodium fluoride therapy the soft tissue calcifications disappeared almost completely. High bone turnover may account for the accelerated deveopment and disappearance of fluorosis in myeloma. Progressive renal failure due to myeloma and, perhaps, increased susceptibility of destructed bone to fluorides advocate restricted use of fluorides in the treatment of osteolytic bone lesions in myeloma.