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[Mould allergy (author's transl)]

W Kersten, G T Hoek

    Wiener Medizinische Wochenschrift (1946)
    |April 30, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Skin tests and inhalation tests are crucial for diagnosing mould sensitivity in allergic asthma patients. While some moulds show cross-reactivity, provocative inhalation tests are essential for definitive diagnosis, as RAST results are often inconclusive.

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    Area of Science:

    • Allergy and Immunology
    • Respiratory Medicine
    • Environmental Health

    Background:

    • Mould allergens are implicated in allergic respiratory diseases, including asthma.
    • Accurate diagnosis of mould sensitivity is essential for effective patient management.
    • The diagnostic utility of various tests for mould allergy requires clarification.

    Purpose of the Study:

    • To investigate the relationship between skin tests, inhalation provocation tests, and RAST for common mould allergens in asthmatic patients.
    • To determine the prevalence of mould sensitivity in allergic asthmatic individuals.
    • To assess the diagnostic value of different testing methods for mould-induced asthma.

    Main Methods:

    • Retrospective analysis of 290 asthmatic patients with positive skin tests to mould allergens.

    Related Experiment Videos

  • Evaluation of skin tests, inhalation provocation tests, and RAST (Radioallergosorbent test) for specific moulds (Alternaria alternata, Aureobasidium pullulans, Penicillium notatum, Fusarium culmorum, Aspergillus fumigatus, Cladosporium herbarum).
  • Assessment of correlations between test results and clinical allergy, including polyvalent mould sensitivity.

    • Main Results:

    • Approximately 10% of allergic asthmatic patients exhibit sensitivity to moulds.
    • Alternaria alternata demonstrated a significant role.
    • Skin tests and provocation tests showed the highest correlation with clinical allergy; Penicillia exhibited cross-reactivity, but no other preferential mould combinations were identified.
    • RAST results were generally not decisive for diagnosis.

    Conclusions:

    • Provocative inhalation tests are indispensable for confirming mould sensitivity when suspected in asthmatic patients.
    • Skin testing provides valuable information, but should be complemented by inhalation challenges.
    • Current RAST assays have limited diagnostic utility for mould allergy in this cohort.