Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Optic neuritis as an initial symptom in multiple sclerosis

J Wikström, S Poser, G Ritter

    Acta Neurologica Scandinavica
    |March 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Osteonecrosis not exclusively confined to the jawbones.

    British dental journal·2025
    Same author

    How much resources are reasonable to spend on radiological protection?

    Journal of radiological protection : official journal of the Society for Radiological Protection·2024
    Same author

    High Intravascular Signal Arterial Transit Time Artifacts Have Negligible Effects on Cerebral Blood Flow and Cerebrovascular Reserve Capacity Measurement Using Single Postlabel Delay Arterial Spin-Labeling in Patients with Moyamoya Disease.

    AJNR. American journal of neuroradiology·2020
    Same author

    Evaluation of the INTERPRET decision-support system: can it improve the diagnostic value of magnetic resonance spectroscopy of the brain?

    Neuroradiology·2018
    Same author

    Characterizing ice particles using two-dimensional reflections of a lidar beam.

    Applied optics·2017
    Same author

    Guidelines for the use of magnetic resonance imaging in diagnosing and monitoring the treatment of multiple sclerosis: recommendations of the Swedish Multiple Sclerosis Association and the Swedish Neuroradiological Society.

    Acta neurologica Scandinavica·2016
    Same journal

    Editorial.

    Acta neurologica Scandinavica·2022
    Same journal

    Advances in sudden unexpected death in epilepsy.

    Acta neurologica Scandinavica·2022
    Same journal

    Non-convulsive seizures and non-convulsive status epilepticus in neuro-intensive care unit.

    Acta neurologica Scandinavica·2022
    Same journal

    Positron emission tomography in autoimmune encephalitis: Clinical implications and future directions.

    Acta neurologica Scandinavica·2022
    Same journal

    Seizure detection based on wearable devices: A review of device, mechanism, and algorithm.

    Acta neurologica Scandinavica·2022
    Same journal

    Walking confidence and perceived locomotion ability explain participation after stroke: A cross-sectional experimental study.

    Acta neurologica Scandinavica·2022
    See all related articles

    Optic neuritis (ON) as an initial sign of multiple sclerosis (MS) does not predict a favorable long-term prognosis. While ON may indicate an earlier disease onset, it does not correlate with reduced disability over time.

    Area of Science:

    • Neurology
    • Neuroimmunology
    • Ophthalmology

    Background:

    • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
    • Optic nerve involvement, specifically optic neuritis (ON), is a common initial symptom in MS.
    • Understanding the prognostic value of initial ON is crucial for patient management.

    Purpose of the Study:

    • To investigate the long-term impact of optic neuritis (ON) as the sole initial sign of multiple sclerosis (MS) on disease course and disability.
    • To determine if initial ON is a favorable prognostic indicator in MS.
    • To analyze demographic and clinical features associated with initial ON in MS patients.

    Main Methods:

    • Multicenter documentation system analysis of 1271 multiple sclerosis (MS) patients.

    Related Experiment Videos

  • Standardized data collection on disease onset, symptoms, and disability.
  • Statistical analysis of demographic data, clinical signs, and disease duration in relation to initial optic neuritis (ON).

    • Main Results:

    • Optic neuritis (ON) was the initial sign in 16.6% of MS patients and involved the optic nerve in 34.7%.
    • Patients with initial ON as the sole sign had a lower mean age of onset (29.0 years) compared to the overall MS cohort (31.1 years).
    • Contrary to previous beliefs, initial ON was not associated with a better long-term prognosis or lower frequency of specific neurological signs (brainstem/cerebellar, pyramidal) over time.

    Conclusions:

    • Initial optic neuritis (ON) in multiple sclerosis (MS) does not appear to be a favorable prognostic sign for the later course of the disease.
    • Initial ON may be a more precise indicator of the mean age of MS onset than other initial symptoms.
    • The findings suggest that the prognostic implications of initial ON require re-evaluation in the context of long-term MS progression.