Cystamine effect on the pharmacokinetics of imipramine in radiation sickness

Investigations were carried out on the effect of cystamine premedication (100 mg/kg) before irradiation with 600 R on imipramine (40 mg/kg) kinetics in male Wistar rats. It was found that cystamine prevented changes in blood imipramine level in the irradiated animals but it protected additionally the process of drug elimination from the blood (T 1/2 beta in controls = 1.67 h, in irradiated = 2.38 h, in irradiated premedicated = 4.01 h).