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Related Experiment Videos

Increased fetal breathing activity after fetal hypophysectomy

J S Robinson, E J Kingston, G D Thorburn

    American Journal of Obstetrics and Gynecology
    |July 15, 1980
    PubMed
    Summary

    Fetal pituitary removal significantly increased fetal breathing movements in sheep. This suggests the pituitary gland plays a role in regulating fetal breathing patterns before birth.

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    Area of Science:

    • Reproductive Physiology
    • Developmental Neuroscience

    Background:

    • Fetal breathing movements are crucial for lung development.
    • The role of the fetal pituitary in regulating breathing is not fully understood.

    Purpose of the Study:

    • To investigate the effect of fetal hypophysectomy on fetal breathing movements in sheep.
    • To explore potential pituitary regulation of fetal respiratory patterns.

    Main Methods:

    • Continuous tracheal pressure recordings in control and hypophysectomized fetal sheep.
    • Surgical intervention included attempted hypophysectomy and accidental destruction of brain structures.

    Main Results:

    • Hypophysectomy led to a significant increase in fetal breathing movements (38.1 min/hr vs. 24.5 min/hr, p < 0.001).
    • Breathing patterns included prolonged, regular, and irregular movements, with one pattern resembling neonatal quiet sleep breathing.
    • Destruction of the forebrain and brain stem abolished fetal breathing movements.

    Conclusions:

    • The fetal pituitary gland appears to inhibit fetal breathing movements.
    • Fetal breathing exhibits complex patterns, including those similar to postnatal breathing, suggesting developmental continuity.
    • Central nervous system structures are essential for generating fetal breathing.

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