Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Computer modeling, complex biological systems, and their simplifications

The American Journal of Physiology

|July 1, 1980

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Medical Problems on a Professional Baseball Team.

The Physician and sportsmedicine·2016

Same author

Headache in Athletes.

The Physician and sportsmedicine·2016

Same author

Facilitation of benzodiazepine discontinuation by melatonin: a new clinical approach.

Archives of internal medicine·2000

Same author

Antioxidants and aging: is melatonin a possible, practical new hope?

Nutrition (Burbank, Los Angeles County, Calif.)·1998

Same author

The use of melatonin for sleep.

Nutrition (Burbank, Los Angeles County, Calif.)·1998

Same author

Improvement of sleep quality by controlled-release melatonin in benzodiazepine-treated elderly insomniacs.

Archives of gerontology and geriatrics·1997

Same journal

Blood coagulation in fish.

The American journal of physiology·2011

Same journal

Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

The American journal of physiology·2010

Same journal

The inactivation of placental toxin by human serum.

The American journal of physiology·2010

Same journal

Adrenal function following ovariectomy in the rat.

The American journal of physiology·2010

Same journal

Capillary permeability; perfusion of frog and guinea pig hind limbs.

The American journal of physiology·2010

Same journal

Evaluation of protective measures against sunburn.

The American journal of physiology·2010

See all related articles

Biological systems contain vast genomic information exceeding human short-term memory. Simplifying complex biological data is common but limiting; computer simulations offer a powerful alternative for analysis.

Area of Science:

Systems Biology
Bioinformatics
Computational Biology

Background:

Biological systems possess complex genomic information exceeding human cognitive limits.
The human mind simplifies complex data, potentially limiting accurate interpretation of biological experiments.
Traditional methods like Michaelis-Menten models, while useful, may oversimplify biological realities.

Purpose of the Study:

To highlight the limitations of human cognitive processing in understanding complex biological systems.
To discuss the role of simplification and linearization in biological data interpretation.
To introduce computer simulation as a viable alternative for analyzing complex biological systems.

Main Methods:

Analysis of cognitive limitations in handling biological information.

Related Experiment Videos

Discussion of simplification and linearization in scientific interpretation.

Exploration of computer simulation for nonlinear biological systems.

Main Results:

Human short-term memory struggles with the vast information in biological genomes.
Simplification strategies, though common, can hinder accurate experimental interpretation in biology.
Computer simulation offers a method to study complex biological systems without excessive simplification.

Conclusions:

Over-reliance on simplification in biology can be a significant limitation.
Computer simulation presents a more comprehensive approach to understanding complex biological systems.
Advancements in computational power make simulations increasingly practical for biological research.