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[Cardiovascular changes caused by nicotinic acid (author's transl)]
Anasthesie, Intensivtherapie, Notfallmedizin
|April 1, 1980
Summary
Nicotinic acid (niacin) temporarily lowers arterial pressure and resistance, but does not improve blood flow to poststenotic areas. This vascular effect is not due to adrenergic blockade, suggesting potential therapeutic uses.
Area of Science:
- Cardiovascular Research
- Pharmacology
Background:
- Nicotinic acid's vascular effects are not fully understood.
- Potential therapeutic applications in conditions like
Purpose of the Study:
- To investigate the cardiovascular effects of intravenous nicotinic acid before arterial-femoral-bypass (AFB) surgery.
- To determine if nicotinic acid can improve blood supply to poststenotic regions.
Main Methods:
- Quantitative examination and statistical analysis of 11 cardiovascular parameters in 23 patients.
- Assessment of vascular effects and exclusion of adrenergic blockade as the mechanism.
Main Results:
- A transient decrease in arterial pressure and resistance was observed following nicotinic acid administration.
- The study did not support the use of nicotinic acid for increasing blood supply to poststenotic regions.
- The vascular effects were confirmed to be independent of adrenergic blockade.
Conclusions:
- Nicotinic acid's transient hypotensive and resistance-lowering effects may not benefit poststenotic circulation and could potentially impair it.
- Findings support the potential of nicotinic acid in managing "shock lung" due to its fibrinolytic properties and short-term hemodynamic effects.
- Nicotinic acid may counteract Disseminated Intravascular Coagulation and reduce pulmonary edema risk by temporarily decreasing vascular pressure and resistance.