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Updated: Oct 13, 2026

Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice
Published on: December 29, 2016
[Circulatory changes in neurosurgical patients with intracerebral angiomas in neuroleptanaesthesia (author's transl)]
Abstract:
In 10 neurosurgical patients with intracerebral angiomas circulatory and respiratory functions were studied. After induction of anesthesia the cardiac output declined from an average value of 7.63 +/- 2.13 1.min-1 to 3.99 +/- 0.43 1.min-1 (-48%) in consequence to the decline of the heart rate by 24% and the stroke volume by 32%. In the same time increased the calculated peripheral resistance in reverse proportion to the decline of the cardiac output by 47%. The oxygen transport decreased after induction of anaesthesia by 48% while the oxygen uptake decreased by 28.6%. The oxygen utilization coefficient increased by 48% (0.33) and documented a satisfactory relation between oxygen-uptake and oxygen utilization in neuroleptanaesthesia.

