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Complement activation during cardiopulmonary bypass

P L Haslam, P J Townsend, M A Branthwaite

    Anaesthesia
    |January 1, 1980
    PubMed
    Summary
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    Complement component C3 conversion was detected in stored blood and during cardiac surgery. This complement activation may contribute to tissue injury following cardiopulmonary bypass procedures.

    Area of Science:

    • Immunology
    • Biochemistry
    • Surgical Science

    Background:

    • The complement system is a crucial part of innate immunity.
    • Complement component C3 (C3) plays a central role in complement activation.
    • Understanding C3 conversion is vital for assessing immune responses and potential tissue damage.

    Purpose of the Study:

    • To investigate the occurrence and implications of C3 conversion.
    • To determine if C3 conversion is associated with specific clinical conditions.

    Main Methods:

    • Utilized a two-dimensional immunoelectrophoretic method to detect C3 conversion.
    • Analyzed samples from stored donor blood and patients undergoing specific surgical procedures.

    Main Results:

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    • C3 conversion was evidenced in stored donor blood.
    • Evidence of C3 conversion was found in patients during and after cardiopulmonary bypass.
    • Occasional C3 conversion was observed during pulmonary resection surgery (thoracotomy).

    Conclusions:

    • Complement activation, indicated by C3 conversion, occurs in stored blood and during specific surgical interventions.
    • Complement activation is a potential contributing factor to tissue injury following cardiopulmonary bypass.