Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amnesic action of midazolam

J W Dundee, D B Wilson

    Anaesthesia
    |May 1, 1980
    PubMed
    Summary

    Midazolam, a benzodiazepine drug, temporarily impairs adult memory for visual information shortly after intravenous injection. This memory impairment effect from midazolam largely resolves within 20 minutes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Prostaglandins in peptic ulcer disease.

    Postgraduate medicine·2016
    Same author

    Screening cerebrovascular patients for silent myocardial ischemia with stress testing and ambulatory left ventricular function monitor.

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
    Same author

    Idiotypic regulation of self-reactive and allo-reactive T cells in autoimmunity and graft-versus-host disease.

    Immunology today·2014
    Same author

    The statistical picture of Michigan hospitals.

    Hospitals·2010
    Same author

    Notes on the use of spray killing against mosquitoes.

    East African medical journal·2010
    Same author

    Malaria in Abyssinia.

    East African medical journal·2010

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Cognitive Psychology

    Background:

    • Midazolam is a widely used water-soluble benzodiazepine.
    • Benzodiazepines are known to cause sedation and amnesia.
    • Understanding the time course of cognitive impairment is crucial for clinical practice.

    Purpose of the Study:

    • To investigate the acute effects of midazolam on short-term memory in adults.
    • To determine the onset and duration of memory impairment following intravenous midazolam administration.

    Main Methods:

    • Adult participants received an intravenous injection of midazolam 5 mg.
    • Memory recall for postcards was assessed at specific time points post-injection.
    • The time course of memory impairment was evaluated.

    Main Results:

    • A maximum effect of impaired memory for visual stimuli (postcards) was observed between 2 and 5 minutes after midazolam injection.
    • The memory impairment effect significantly diminished by 20 minutes post-injection.

    Conclusions:

    • Intravenous midazolam at a 5 mg dose causes transient, short-term memory impairment in adults.
    • The cognitive effects of midazolam on memory are relatively short-lived, with significant recovery within 20 minutes.

    Related Experiment Videos