[Surface activity of polyene antibiotics]

The surface activity properties of polyenic antibiotics, such as amphotericin B, mycoheptin, levorin and nystatin were studied. The critical concentrations for the mycella formation were determined and the values of the polyenic antibiotic surface activity at various temperatures were estimated. It was found that the process of the mycella formation of polyenic antibiotics was defined by a positive change in the entropy. A thermodynamic analysis of the process of the mycella formation of the polyenic antibiotics in aqueous solutions was performed.