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Related Concept Videos

Toxoplasmosis01:28

Toxoplasmosis

Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...

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Related Experiment Video

Updated: Jul 20, 2026

Toxoplasma gondii Cyst Wall Formation in Activated Bone Marrow-derived Macrophages and Bradyzoite Conditions
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Behavioural abnormalities in Toxoplasma-infected mice

W M Hutchinson, M Bradley, W M Cheyne

    Annals of Tropical Medicine and Parasitology
    |June 1, 1980
    PubMed
    Summary

    Toxoplasma infection alters mouse behavior, increasing general movement while decreasing rearing and digging. These changes suggest the parasite impacts the host's environmental responses and brain regulation.

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    Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity

    Published on: March 12, 2015

    Area of Science:

    • Neuroparasitology
    • Animal Behavior Studies
    • Infectious Disease Research

    Background:

    • Toxoplasma gondii is a widespread protozoan parasite known to infect a wide range of hosts, including rodents.
    • Parasitic manipulation of host behavior is a recognized phenomenon, potentially influencing host survival and transmission.
    • Understanding behavioral changes in infected rodents is crucial for comprehending host-parasite interactions.

    Purpose of the Study:

    • To investigate the specific behavioral alterations in mice infected with Toxoplasma.
    • To analyze the impact of infection on general movement, specific behaviors (rearing, digging), and behavioral bout patterns.
    • To elucidate the potential mechanisms by which Toxoplasma influences host neurobiology and environmental responses.

    Main Methods:

    • Utilized observational methods with video recordings for detailed behavioral analysis.
    • Employed computer-assisted data analysis to quantify behavioral changes.
    • Focused on assessing general activity, rearing, digging, and the pattern of behavioral bouts in infected mice.

    Main Results:

    • Toxoplasma infection selectively increased general movement in mice.
    • Infection led to a decrease in rearing and digging behaviors.
    • Behavioral patterns shifted, characterized by an increase in shorter behavioral bouts, underlying specific changes.

    Conclusions:

    • Toxoplasma infection significantly modifies host behavior, affecting motor activity and exploratory actions.
    • The observed behavioral changes suggest an altered host response to environmental stimuli.
    • The findings indicate a potential impact of Toxoplasma on endogenous regulatory processes within the host's brain.