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Detecting unsuspected thyroid dysfunction by the free thyroxine index

L V dos Remedios, P M Weber, R Feldman

    Archives of Internal Medicine
    |August 1, 1980
    PubMed
    Summary
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    The free thyroxine index (FTI) effectively detects thyroid dysfunction in adults. This cost-effective screening method accurately identifies hyperthyroidism and hypothyroidism, aiding in early diagnosis and treatment.

    Area of Science:

    • Endocrinology
    • Clinical Diagnostics

    Background:

    • Thyroid dysfunction is a common endocrine disorder.
    • Early detection of thyroid dysfunction is crucial for effective management.

    Purpose of the Study:

    • To evaluate the cost-effectiveness of the free thyroxine index (FTI) for detecting unsuspected thyroid dysfunction in adults.
    • To determine the prevalence and incidence of thyroid dysfunction in the studied population.

    Main Methods:

    • A study involving 2,704 adults utilized the free thyroxine index (FTI) for screening.
    • Analysis included assessment of FTI accuracy, sensitivity, specificity, and predictive value.

    Main Results:

    • The FTI demonstrated high accuracy, with a sensitivity of 1.0 and specificity of 0.996.

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  • Newly diagnosed thyroid dysfunction was found in 25 subjects (0.81% prevalence).
  • The cost per identified case averaged $127, indicating cost-effectiveness.

    • Conclusions:

    • The free thyroxine index (FTI) is a cost-effective tool for identifying thyroid dysfunction.
    • The study supports the use of FTI in clinical practice for case finding.