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[Prolactin adenomas in children (author's transl)]
Archives Francaises De Pediatrie
|February 1, 1980
Summary
Pediatric prolactin (PRL) secreting adenomas present with growth issues or pubertal disturbances. Early diagnosis and treatment with surgery or bromocriptine are crucial for favorable outcomes.
Area of Science:
- Pediatric Endocrinology
- Neuroendocrinology
- Oncology
Background:
- Prolactin (PRL) secreting adenomas are rare in children.
- Early diagnosis is often delayed due to nonspecific symptoms.
Purpose of the Study:
- To analyze clinical manifestations, diagnosis, and treatment outcomes of pediatric PRL secreting adenomas.
Main Methods:
- Retrospective study of 12 patients with PRL secreting adenomas diagnosed before age 15.
- Clinical data, hormonal levels, imaging, and treatment responses were reviewed.
Main Results:
- Presentations included growth arrest, pubertal delay, amenorrhea, galactorrhea, and gynecomastia.
- Most tumors were large (11/12) and invasive (7/12), with elevated plasma PRL levels.
- Symptomatic presentation (headaches, visual disturbances) occurred in 11/12 patients.
Conclusions:
- Pediatric PRL secreting adenomas require prompt recognition and management.
- Treatment options include surgery and bromocriptine, with prognosis linked to short-term outcomes.