Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ideal sampling time for drug assays

P W Nicholson, S M Dobbs, E M Rodgers

    British Journal of Clinical Pharmacology
    |May 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Estimating mean drug concentration requires knowing sample timing and individual pharmacokinetics. A sampling time of 11 hours after dosing is proposed as ideal for drugs with long half-lives, simplifying therapeutic drug monitoring.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Physiological performance of common carp (Cyprinus carpio, L., 1758) exposed to a sublethal copper/zinc/cadmium mixture.

    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP·2020
    Same author

    Transdisciplinary synthesis for ecosystem science, policy and management: The Australian experience.

    The Science of the total environment·2015
    Same author

    Morphological and molecular variation in the least madtom Noturus hildebrandi (Siluriformes: Ictaluridae), a Mississippi Embayment endemic: evidence for a cryptic lineage in the Hatchie River.

    Journal of fish biology·2015
    Same author

    Significantly higher frequency of Helicobacter suis in patients with idiopathic parkinsonism than in control patients.

    Alimentary pharmacology & therapeutics·2013
    Same author

    Prescribing aids for gentamicin.

    British journal of clinical pharmacology·2012
    Same author

    Serum digoxin concentrations.

    British journal of clinical pharmacology·2012

    Area of Science:

    • Pharmacokinetics
    • Pharmacology
    • Clinical Chemistry

    Background:

    • Accurate estimation of mean steady-state drug concentrations from single samples is challenging.
    • Requires knowledge of sampling time within the dose interval and individual pharmacokinetic parameters.
    • Digoxin maintenance therapy in outpatients provides a model for evaluating drug concentration estimation.

    Purpose of the Study:

    • To derive a relationship between serum drug concentration at any given time and mean steady-state concentration.
    • To identify an ideal sampling time for therapeutic drug monitoring.
    • To establish conditions for extending this approach to other drugs.

    Main Methods:

    • Theoretical modeling of a one-compartment pharmacokinetic model with first-order elimination.

    Related Experiment Videos

  • Analysis of serum digoxin concentration data from 80 outpatients.
  • Derivation of the ratio C/C (concentration at time C / mean steady-state concentration) based on half-life, dose interval, and sampling time.

    • Main Results:

    • The ratio C/C is theoretically dependent on drug half-life, dose interval, and sampling time.
    • An 11-hour sampling time after a daily dose is identified as an ideal time for drugs with longer half-lives.
    • For orally administered digoxin, the 11-hour sampling ratio (0.97) closely approximates theoretical models.

    Conclusions:

    • An 11-hour sampling time can simplify therapeutic drug monitoring for drugs with long half-lives (≥15 hours).
    • This method is applicable to drugs with concentration-time curves approximating exponential decay.
    • The derived principles allow for the identification of ideal sampling times for various dosing intervals and drugs.