Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet factor 4 regulates osteoclastic bone resorption in vitro

J E Horton, J Harper, E Harper

    Biochimica Et Biophysica Acta
    |July 3, 1980
    PubMed
    Summary

    Platelet factor 4 inhibits parathyroid hormone-stimulated calcium release from fetal rat bone. This factor effectively blocks bone resorption, regardless of whether it is active or initiating.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Tabular foundation model predicts alternative lengthening of telomeres (ALT) and identifies SMARCAL1 as a target in ALT-driven cancers.

    bioRxiv : the preprint server for biology·2026
    Same author

    Good practice recommendations on add-ons in reproductive medicine†.

    Human reproduction (Oxford, England)·2023
    Same author

    Review: Improving pig survival with a focus on birthweight: a practical breeding perspective.

    Animal : an international journal of animal bioscience·2023
    Same author

    Stimulating fertility awareness: the importance of getting the language right.

    Human reproduction open·2023
    Same author

    A novel treatment for supraglottic stenosis secondary to immunoglobulin G4-related disease.

    Annals of the Royal College of Surgeons of England·2021
    Same author

    Catheter-associated bloodstream infections in adults with cancer: a prospective randomized controlled trial.

    The Journal of hospital infection·2020

    Area of Science:

    • Biochemistry
    • Bone Biology
    • Endocrinology

    Background:

    • Platelet factor 4 (PF4) is known to inhibit collagenases.
    • Parathyroid hormone (PTH) stimulates bone resorption.
    • Calcium-45 (45Ca) is a radiotracer used to study bone mineral metabolism.

    Purpose of the Study:

    • To investigate the effect of Platelet factor 4 (PF4) on parathyroid hormone (PTH)-stimulated bone resorption.
    • To determine if PF4's inhibitory action on bone resorption is dependent on the resorption state.

    Main Methods:

    • In vitro study using fetal rat bone.
    • Measurement of 45Ca release as an indicator of bone resorption.
    • Exposure of bone to PTH with and without PF4.

    Main Results:

    • PF4 reversibly inhibited PTH-stimulated 45Ca release from fetal rat bone.
    • PF4 demonstrated inhibitory effects on both actively resorbing and initiating resorption bone models.
    • The inhibitory effect of PF4 was consistent across different resorption states.

    Conclusions:

    • Platelet factor 4 possesses an inhibitory effect on PTH-induced bone resorption in vitro.
    • PF4 may play a role in regulating bone resorption processes.
    • The findings suggest PF4 as a potential modulator of bone metabolism.

    Related Experiment Videos