[Effect of toxic liver lesions on the generative function of rats]

Hepatic lesions in white rats were produced by administering the hepatotropic alkaloid heliotrin. Four series of experiments in different combinations were conducted (poisoning of female and male rats alone and simultaneously with subsequent crossing). The animals with heliotrin-induced hepatitis showed a tendency to a later coming of conception, to a decreased number of fetuses, and their unequal distribution in uterine horns. The morphologic appearance of the ovaries exposed to heliotrin was examined. The evidence obtained indicates that in toxic hepatitis (apparently in infectious hepatitis as well) the generative function gets destroyed that can be seen from changes in coming, developing, preserving and completion of pregnancy.