[Effect of trypsin on intravascular erythrocytes aggregation]

The role of proteolytic enzymes in intravascular aggregation of red cells was studied in experiments on rats by intravital microscopy. Intravenous injection of trypsin (40--50 mg/kg) combined with heparin (1000 units/kg) produces marked intravascular aggregation of red cells. Preliminary infusion of pentoxyphyllin (20 mg/kg) or acetylsalicylic acid (100 mg/kg) blocked this process. A conclusion is made about an important role of proteolytic enzymes play in the development of microcirculatory disorders. A possible mechanism of the aggregating action of trypsin and approaches to its correction are discussed.