[Electron microscopic and histochemical characteristics of hepatomas arising during long-term administration of...

Hepatomas arising as a result of prolonged injection of CCl4 consist of cells in which the processes of dystrophy and intracellular regeneration are pronounced to a different degree. In the late stages of development, hepatomas tend to malignancy, exhibiting cells that bear ultrastructural resemblance to the cells of malignant hepatomas. Histological examination revealed high aerobic glycolysis and decreased activity of oxidizing enzymes. Discontinuance of CCl4 injection did not entail normalization of the liver structure. The sinusoidal cells are likely to play an essential role in the development of intralobular liver fibrosis.