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Serum ferritin: physiological and methodological studies

G Birgegård

    Clinica Chimica Acta; International Journal of Clinical Chemistry
    |May 9, 1980
    PubMed
    Summary
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    Serum ferritin levels show minimal day-to-day variation and are stable under various storage conditions. Hemolysis and moderate alcohol intake do not significantly impact these ferritin measurements.

    Area of Science:

    • Clinical Biochemistry
    • Hematology

    Background:

    • Ferritin is a key protein for iron storage.
    • Understanding ferritin physiology and measurement variability is crucial for accurate clinical interpretation.

    Purpose of the Study:

    • To investigate normal ferritin physiology.
    • To assess methodological issues affecting ferritin testing, including sample handling and stability.

    Main Methods:

    • Assessed circadian rhythm and day-to-day variation in ferritin levels.
    • Quantified ferritin content in erythrocytes and leucocytes.
    • Evaluated the impact of sample hemolysis, storage conditions, anticoagulants, and alcohol consumption on serum ferritin concentrations.

    Main Results:

    • No significant circadian rhythm in ferritin levels was observed.

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  • Mean day-to-day variation was 9%, with individual variability noted.
  • Serum ferritin remained stable after hemolysis (up to 3 g/l hemoglobin), prolonged storage (-20°C for 1 year), and multiple freeze-thaw cycles.
  • EDTA plasma yielded lower ferritin values (23% decrease) compared to serum, heparin, or citrate plasma.
  • Moderate alcohol consumption did not elevate serum ferritin levels within 56 hours.

    • Conclusions:

    • Serum ferritin measurements are generally reliable and stable under common pre-analytical conditions.
    • EDTA plasma should be avoided for accurate ferritin quantification.
    • Standard laboratory procedures for sample handling and storage are suitable for ferritin testing.