Related Experiment Video

Updated: Aug 24, 2026

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
10:54

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry

Published on: February 4, 2017

Tissue distribution of orally administered bismuth in the rat

S P Lee, T H Lim, J Pybus

    Clinical and Experimental Pharmacology & Physiology
    |May 1, 1980
    PubMed

    More Related Videos

    Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung07:10

    Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung

    Published on: May 20, 2019

    Microsurgical Skills of Establishing Permanent Jugular Vein Cannulation in Rats for Serial Blood Sampling of Orally Administered Drug08:28

    Microsurgical Skills of Establishing Permanent Jugular Vein Cannulation in Rats for Serial Blood Sampling of Orally Administered Drug

    Published on: December 14, 2021

    Related Concept Videos

    Bioavailability: Overview01:13

    Bioavailability: Overview

    Bioavailability refers to the proportion of an unaltered drug that, after administration, enters the systemic circulation and can be distributed to the desired action site. Factors such as gastrointestinal (GI) absorption and liver biotransformation influence the bioavailability of a drug when it is administered orally. When a drug is administered intravenously, it enters the systemic circulation directly; by definition, its bioavailability is assumed to be 100%. The bioavailability of an...
    Compartment Models: Two-Compartment Model01:20

    Compartment Models: Two-Compartment Model

    The two-compartment model divides the body into central and peripheral compartments to account for varying blood perfusion rates among organs and tissues, affecting drug distribution. The central compartment includes blood and highly perfused tissues with rapid drug distribution, while the peripheral compartment contains tissues with slower drug distribution. After a single IV bolus dose, the drug concentration is high in plasma and low in tissues. The drug distribution between compartments...
    Methods for Studying Drug Absorption: In situ01:09

    Methods for Studying Drug Absorption: In situ

    In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
    The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
    Factors Affecting Drug Distribution: Organ Perfusion Rate01:15

    Factors Affecting Drug Distribution: Organ Perfusion Rate

    Drug distribution within the body is a complex process influenced by several factors, including perfusion rate, the rate at which the bloodstream transports drugs to tissue. This limitation becomes particularly significant when dealing with highly lipophilic drugs. In such cases, the rate at which the drug can move across membranes is crucial, and if the membrane is highly permeable to the drug, distribution becomes rate-limited by perfusion.
    Perfusion rate-limited distribution relies on the...
    Bioavailability: Overview01:17

    Bioavailability: Overview

    Bioavailability refers to the proportion of an administered drug that reaches the systemic circulation in its active, unaltered form. It is a crucial pharmacokinetic parameter that determines the effectiveness of a drug in achieving its intended therapeutic outcomes. The route of administration significantly influences bioavailability, with intravenous administration achieving 100% bioavailability as the drug directly enters the bloodstream. In contrast, oral administration often results in...