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Related Experiment Videos

Plasma timolol levels and systolic time intervals

B N Singh, F M Williams, R M Whitlock

    Clinical Pharmacology and Therapeutics
    |August 1, 1980
    PubMed
    Summary

    Timolol exhibits significantly greater beta-blocking potency than propranolol. Both drugs demonstrate clinical practicality for twice-daily dosing in patients with coronary artery disease and healthy subjects.

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    Area of Science:

    • Pharmacology
    • Cardiovascular Medicine

    Background:

    • Beta-blockers like timolol and propranolol are crucial in managing cardiovascular conditions.
    • Understanding their comparative potency and effects on cardiac function is essential for optimal therapeutic strategies.

    Purpose of the Study:

    • To compare the beta-blocking potency of timolol and propranolol.
    • To evaluate the effects of timolol on systolic time intervals in healthy individuals and patients with coronary artery disease.
    • To assess the relationship between timolol dosage, plasma concentration, and its beta-blocking effects.

    Main Methods:

    • Comparative study involving eight healthy subjects and six patients with coronary artery disease.
    • Assessment of beta-blocking potency via inhibition of exercise-induced tachycardia.
    • Evaluation of systolic time intervals under varying timolol dose schedules and plasma concentrations.

    Main Results:

    • Timolol was found to be eight times more potent than propranolol in its beta-blocking effects.
    • A linear correlation was observed between timolol dose and its beta-blocking effect (r = 0.98).
    • Equipotent doses of timolol and propranolol prolonged specific systolic time intervals in patients with coronary artery disease.

    Conclusions:

    • Timolol demonstrates superior beta-blocking potency compared to propranolol.
    • Twice-daily dosing of both timolol and propranolol appears clinically practical, showing significant beta-blocking effects at the end of a 12-hour schedule.
    • The study highlights the potential clinical utility of timolol and propranolol in cardiovascular therapy.

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