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Related Experiment Videos

Podophyllum: suspected teratogenicity from topical application

M D Karol, C S Conner, A S Watanabe

    Clinical Toxicology
    |May 1, 1980
    PubMed
    Summary

    Topical podophyllum use during pregnancy may cause birth defects. This case study highlights potential teratogenic effects, including a simian crease and skin tag, and suggests avoiding this treatment during gestation.

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    Area of Science:

    • Obstetrics and Gynecology
    • Dermatology
    • Teratology

    Background:

    • Topical podophyllum resin is a common treatment for external genital warts.
    • Pregnancy necessitates careful consideration of medication safety due to potential teratogenic risks.

    Observation:

    • A pregnant individual received topical podophyllum applications between 23 and 29 weeks gestation for wart treatment.
    • The treatment involved five applications, each lasting 4 hours.

    Findings:

    • The infant presented with a simian crease on the left hand and a preauricular skin tag at birth.
    • These findings are suspected teratogenic effects linked to maternal podophyllum exposure.

    Implications:

    • Podophyllum resin should be avoided during pregnancy due to potential risks of congenital anomalies.
    • Alternative, safer treatments for warts in the vaginal, perineal, or anal areas during pregnancy should be considered.

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