Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Atenolol 4% eyedrops in glaucoma simplex

C C Sterk

    Documenta Ophthalmologica. Advances in Ophthalmology
    |April 15, 1980
    PubMed
    Summary

    A single dose of atenolol 4% eye drops lowered intraocular pressure more in glaucoma patients than in healthy individuals. However, its effectiveness may decrease over time due to tachyphylaxis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Late ophthalmological complications after total body irradiation in non-human primates.

    International journal of radiation biology·2001
    Same author

    The effect of 1% apraclonidine on intraocular pressure after cataract surgery.

    Ophthalmic surgery and lasers·1998
    Same author

    Decreased basal tear turnover in patients with untreated primary open-angle glaucoma.

    American journal of ophthalmology·1995
    Same author

    Is glaucoma associated with an increased risk of cataract?

    The British journal of ophthalmology·1995
    Same author

    Recurrent herpetic keratitis in penetrating keratoplasty.

    Documenta ophthalmologica. Advances in ophthalmology·1995
    Same author

    The effect of high-intensity focused ultrasound on intraocular pressure in therapy-resistant glaucoma 3-4 months and 1 year after treatment.

    International ophthalmology·1992

    Area of Science:

    • Ophthalmology
    • Pharmacology

    Background:

    • Glaucoma simplex is a common form of glaucoma.
    • Intraocular pressure (IOP) is a key risk factor for glaucoma progression.

    Purpose of the Study:

    • To evaluate the efficacy of a single dose of topical atenolol 4% in reducing IOP.
    • To compare the IOP-lowering effect of atenolol 4% in normal eyes versus eyes with glaucoma simplex.
    • To investigate the potential for tachyphylaxis with atenolol 4% treatment.

    Main Methods:

    • A single dose of atenolol 4% was administered locally.
    • Intraocular pressure was measured in normal eyes.
    • Intraocular pressure was measured in three groups of eyes diagnosed with glaucoma simplex.

    Main Results:

    • A greater reduction in intraocular pressure was observed in eyes with glaucoma simplex compared to normal eyes.
    • The IOP-lowering effect of atenolol 4% showed a tendency to diminish with repeated exposure, suggesting tachyphylaxis.

    Conclusions:

    • Topical atenolol 4% demonstrates efficacy in reducing intraocular pressure in glaucoma patients.
    • The development of tachyphylaxis may limit the long-term utility of atenolol 4% as a monotherapy or adjunctive treatment for glaucoma.

    Related Experiment Videos