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The Mongolian gerbil in aging research

A L Vincent, G E Rodrick, W A Sodeman

    Experimental Aging Research
    |June 1, 1980
    PubMed
    Summary

    The Mongolian gerbil is a suitable model for aging research, showing spontaneous neoplasms and similarities to human periodontal disease. However, it is not ideal for studying cholesterol-induced atherosclerosis.

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    Area of Science:

    • Gerontology
    • Comparative Pathology
    • Animal Models

    Background:

    • The Mongolian gerbil is a rodent recently introduced to biomedical research.
    • Gerbils are moderately prolific, easily maintained, and have a maximum survival of approximately 208 weeks.

    Purpose of the Study:

    • To evaluate the Mongolian gerbil's suitability as a model for aging research.
    • To review factors influencing gerbil morbidity and mortality.

    Main Methods:

    • Literature review of gerbil aging, morbidity, and mortality data.
    • Analysis of spontaneous disease prevalence in gerbils.
    • Assessment of gerbil suitability for specific research models.

    Main Results:

    • Potential causes of mortality include maternal neglect, fighting, and epidemic diseases (Tyzzer's, salmonellosis, pneumonia).
    • Obese or breeding gerbils may develop hyperadrenocorticism, diabetes, and arteriosclerosis.
    • Aged gerbils exhibit a high prevalence of spontaneous neoplasms (adrenal cortex, ovary, skin) and share similarities with human periodontal disease.

    Conclusions:

    • The Mongolian gerbil is a valuable model for aging research, particularly for studying spontaneous neoplasms and periodontal disease.
    • It is a useful model for experimentally-induced stroke but unsuitable for cholesterol-induced atherosclerosis research.

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