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Related Experiment Videos

Absorption of digoxin from a new microencapsulated formulation

B Bergdahl, C Bogentoft, U E Jonsson

    European Journal of Clinical Pharmacology
    |June 1, 1980
    PubMed
    Summary

    This study compared digoxin absorption from enteric-coated granules versus tablets. The enteric coating delayed peak plasma concentrations but did not reduce the overall amount of digoxin absorbed.

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    Area of Science:

    • Pharmacokinetics
    • Drug Delivery Systems

    Background:

    • Digoxin is a cardiac glycoside with a narrow therapeutic index.
    • Optimizing digoxin absorption is crucial for effective treatment and patient safety.

    Purpose of the Study:

    • To compare the pharmacokinetic profile of digoxin from enteric-coated granules versus conventional tablets.
    • To evaluate the impact of enteric coating on digoxin absorption rate and extent.

    Main Methods:

    • A pharmacokinetic study involving eight healthy volunteers under steady-state conditions.
    • Measurement of plasma and urine digoxin concentrations using radioimmunoassay.
    • Comparison of absorption parameters between capsule and tablet formulations.

    Main Results:

    • Peak plasma digoxin concentrations were significantly delayed with enteric-coated capsules (2.6 ± 1 h and 2.6 ± 0.9 h) compared to tablets (1.3 ± 0.7 h).
    • The peak concentrations from capsules were comparable to tablets, with one formulation showing a statistically significant lower peak (p < 0.05).
    • Areas under the plasma concentration-time curves and 24-hour urinary excretion were similar across all formulations, indicating comparable overall absorption.

    Conclusions:

    • The specific enteric coating used for digoxin granules effectively delays absorption.
    • This delay in absorption did not compromise the total amount of digoxin absorbed.
    • Enteric-coated digoxin formulations offer a potential alternative for modified drug release profiles.

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