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Relative bioavailability of a paracetamol suppository

P Seideman, G Alván, R S Andrews

    European Journal of Clinical Pharmacology
    |June 1, 1980
    PubMed
    Summary
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    New paracetamol (acetaminophen) suppositories showed approximately 80% bioavailability compared to tablets. Tablets offered faster absorption and higher peak plasma concentrations in healthy subjects.

    Area of Science:

    • Pharmacology
    • Drug Delivery Systems

    Background:

    • Paracetamol (acetaminophen) is a widely used analgesic and antipyretic.
    • Suppositories offer an alternative route of administration for medications.

    Purpose of the Study:

    • To compare the relative bioavailability of a new paracetamol suppository formulation (Panodil) against oral tablets.
    • To evaluate the pharmacokinetic profiles of paracetamol following rectal and oral administration.

    Main Methods:

    • A pharmacokinetic study was conducted in eight healthy adult subjects.
    • Subjects received paracetamol via suppository and tablet formulations at 0.5 g and 1 g doses.
    • Plasma paracetamol concentrations were measured over time to determine bioavailability and absorption rates.

    Main Results:

    Related Experiment Videos

    • Oral tablets demonstrated faster absorption and achieved higher peak plasma concentrations than suppositories.
    • The relative bioavailability of paracetamol suppositories was approximately 80% compared to the tablet formulations.
    • No evidence of dose-dependent (capacity-limited) elimination was observed for paracetamol at the tested doses.

    Conclusions:

    • Paracetamol suppositories provide a viable alternative, though with lower and slower bioavailability than oral tablets.
    • The 80% bioavailability suggests rectal administration may be suitable when oral intake is not feasible.
    • Further studies could explore factors influencing suppository absorption and patient-specific responses.