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Related Experiment Videos

Enkephalin mydriasis in mice

A D Korczyn, Y Eshel, O Keren

    European Journal of Pharmacology
    |July 25, 1980
    PubMed
    Summary

    Enkephalins, similar to morphine, cause mydriasis (pupil dilation) in mice. However, enkephalins are not involved in the natural regulation of pupillary diameter.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Ophthalmology

    Background:

    • Morphine is a known mydriatic agent in mice.
    • Enkephalins are endogenous opioid peptides with various physiological roles.

    Purpose of the Study:

    • To compare the mydriatic potency and time course of enkephalins versus morphine.
    • To investigate the potential physiological role of enkephalins in pupillary diameter regulation.

    Main Methods:

    • Administered morphine, D-Ala-D-Leu-enkephalin, Met-enkephalin, and Leu-enkephalin to mice to assess mydriasis.
    • Compared the potency and duration of mydriatic effects.
    • Administered naloxone or D-phenylalanine to mice to evaluate the involvement of enkephalins in physiological pupillary control.

    Main Results:

    • Enkephalins induced mydriasis in mice, with varying potencies relative to morphine.
    • The duration of mydriasis was shortest for enkephalins and longest for morphine.
    • Naloxone antagonized the mydriatic effects of all tested agents similarly.
    • Administration of naloxone or D-phenylalanine did not alter basal pupillary diameter in mice.

    Conclusions:

    • Enkephalins possess mydriatic properties in mice.
    • The findings suggest that enkephalins are unlikely to be involved in the physiological regulation of pupillary diameter.

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