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Sequential output-input maturation of kitten motor cortex

I C Bruce, W G Tatton

    Experimental Brain Research
    |January 1, 1980
    PubMed
    Summary
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    Motor cortex neuronal responses mature later than somatosensory responses in kittens. Motor cortex requires somatosensory feedback for function, developing around 60 days postnatally.

    Area of Science:

    • Neuroscience
    • Developmental Neuroscience
    • Motor Control

    Background:

    • Cortical neuronal responses are crucial for motor control.
    • Understanding the developmental timeline of cortical circuits is essential for identifying potential disruptions in motor behavior.

    Purpose of the Study:

    • To investigate the postnatal development of motor and somatosensory cortical neuronal responses in kittens.
    • To determine the maturation timeline of motor cortical output pathways and their dependence on sensory feedback.

    Main Methods:

    • Analysis of average response histograms of single cortical neurons to forelimb displacements.
    • Quantification of background activity, excitatory response latency, percentage of responding neurons, and synaptic effectiveness.
    • Assessment of motor cortical output to alpha-motoneurons via microstimulation.

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    Main Results:

    • Motor cortical neuronal responses to sensory input matured significantly later (55-65 days) than somatosensory cortical neurons (9 days).
    • Motor cortical output pathways to triceps brachii motoneurons emerged between 37-45 days postnatally.
    • Motor cortex functions relying on somatosensory feedback were not operational until approximately 60 days.

    Conclusions:

    • Motor cortical sensory processing develops after the establishment of motor output pathways.
    • The late maturation of motor cortex functions dependent on sensory feedback suggests a critical period for developing normal motor behavior.
    • This kitten model offers a valuable system for studying the postnatal development of neuronal networks involved in motor control.