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Epidermal Langerhans' cells after the prick test for Behçet's disease
Dermatologica
|January 1, 1980
Summary
Behçet
Area of Science:
- Dermatology
- Immunology
- Pathology
Background:
- Behçet's disease is a multisystem inflammatory disorder.
- Langerhans' cells (LHC) play a role in immune responses within the skin.
Purpose of the Study:
- To investigate the changes in Langerhans' cells in the prickle cell layer of patients with Behçet's disease after a prick test.
Main Methods:
- Prick testing was performed on patients with Behçet's disease.
- Skin biopsies were analyzed to count Langerhans' cells and observe their ultrastructure.
Main Results:
- An increased number of Langerhans' cells (LHC) were observed in the prickle cell layer post-prick test.
- Langerhans' cells were found in close proximity to lymphocytes.
- Unique lattice-shaped granules were identified within the mitochondria of Langerhans' cells.
Conclusions:
- The prick test elicits an increase in Langerhans' cells in Behçet's disease patients.
- These cells interact with lymphocytes, suggesting a role in the inflammatory process.
- Mitochondrial alterations in Langerhans' cells may indicate specific cellular responses in Behçet's disease.