[Biochemical polymorphism in a population exposed to environmental pollutants. Importance of studying the problem]

Genetically conditioned interpersonal differences in reactions to identical doses of medicines make us suppose that some of those exposed to environmental pollutants are at a special risk. This is revealed by detection of some biochemical differences in blood, conditioning a special susceptibility to the effect of some toxic substances. Another method is the so called loading test, aimed at observing the personal reaction to innoxious doses of medicines or toxicants. Recently, biochemical tests have been regarded more and more valid; these tests allow to foresee what medicine metabolism will be like in organism and consequently, how extensive the potential risk of the given person is.