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Related Experiment Videos

Inflammatory bowel disease associated circulating immune complexes

B J Kemler, E Alpert

    Gut
    |March 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

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    Circulating immune complexes are elevated in inflammatory bowel disease (IBD) patients, suggesting they are specific to IBD rather than general intestinal damage. This finding may help identify disease-specific antigens.

    Area of Science:

    • Immunology
    • Gastroenterology
    • Pathophysiology

    Background:

    • Circulating immune complexes (CICs) have been observed in inflammatory bowel disease (IBD).
    • The origin of these CICs, whether specific to IBD or indicative of general mucosal damage, remains unclear.

    Purpose of the Study:

    • To investigate whether CICs are specifically associated with IBD or with compromised intestinal barrier function.
    • To compare CIC levels in IBD patients, other colitis patients, and healthy individuals.

    Main Methods:

    • Sera from 86 IBD patients, 18 patients with other colitis, and 42 healthy controls were analyzed.
    • Circulating immune complexes were quantified using a Raji cell radioimmunoassay.

    Main Results:

    Related Experiment Videos

  • Raji-detectable CIC levels were significantly higher in IBD patients compared to healthy controls (P<0.001).
  • CIC levels in patients with pseudomembranous/bacterial colitis were similar to healthy controls.
  • Abnormally high CIC levels were found in approximately 20% of IBD patients, but none of the other colitis patients.

    • Conclusions:

    • The presence of CICs in IBD appears specific to the disease process, not merely a consequence of mucosal damage.
    • The absence of detectable CICs in many IBD patients, even with extraintestinal manifestations, questions their pathogenic role.
    • Disease-related CICs could serve as a target for identifying IBD-specific antigens of potential etiological significance.