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Related Experiment Videos

Cell-mediated immunoprotection in blastomycosis

G C Cozad, C T Chang

    Infection and Immunity
    |May 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Inducing delayed hypersensitivity in mice against Blastomyces dermatitidis using killed yeast cells confers protection against lethal infections. This study highlights a strong correlation between host resistance and delayed hypersensitivity levels.

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    Area of Science:

    • Immunology
    • Mycology
    • Infectious Diseases

    Background:

    • Blastomyces dermatitidis is a fungus causing blastomycosis.
    • Delayed hypersensitivity plays a role in fungal infections.

    Purpose of the Study:

    • To investigate the induction of delayed hypersensitivity to Blastomyces dermatitidis.
    • To determine if induced delayed hypersensitivity protects mice from lethal blastomycosis.

    Main Methods:

    • C57BL/6J mice received subcutaneous injections of Merthiolate-killed B. dermatitidis yeast cells in Freund incomplete adjuvant.
    • Delayed hypersensitivity was assessed using footpad sensitivity tests.
    • Protection was evaluated through mortality tests and organ culture indices.

    Main Results:

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    • Delayed hypersensitivity peaked at day 18 post-injection.
    • Hypersensitive mice showed significant protection against lethal B. dermatitidis infection.
    • Protection correlated closely with the level of delayed hypersensitivity.

    Conclusions:

    • Delayed hypersensitivity can be effectively induced in mice against B. dermatitidis.
    • Induced delayed hypersensitivity provides protection against lethal blastomycosis.
    • Host resistance to B. dermatitidis is closely linked to delayed hypersensitivity levels.