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Updated: Aug 16, 2026
Establishment and Characterization of UTI and CAUTI in a Mouse Model
Published on: June 23, 2015
Pseudomonas urinary tract infection in mice
Abstract:
When Pseudomonas aeruginosa was injected through a catheter into the bladder. Hemorrhage, edema, and vessel engorgement were seen 1 h after challenge. At 3 hours we observed microulceration of the bladder, which rapidly healed and was rarely present after 24 h. Pseudomonas was cultured from 50% of the kidneys at 1 week, and the number of kidneys infected decreased over 4 weeks.
Insights
Pseudomonas aeruginosa infection in the bladder causes initial hemorrhage and edema, with rapid bladder healing. Kidney infections occurred in 50% of cases within a week, decreasing over four weeks.
Area of Science:
- Urology
- Infectious Diseases
- Microbiology
Background:
- Pseudomonas aeruginosa is an opportunistic pathogen.
- Catheterization increases the risk of urinary tract infections.
Purpose of the Study:
- To investigate the pathological effects of Pseudomonas aeruginosa bladder infection.
- To determine the timeline of bladder and kidney involvement following infection.
Main Methods:
- Intravesical catheterization and inoculation of Pseudomonas aeruginosa in a model system.
- Histopathological examination of bladder tissue at various time points.
- Bacterial culture of kidneys to assess infection spread and clearance.
Main Results:
- Early signs of inflammation (hemorrhage, edema, engorgement) observed within 1 hour post-infection.
- Transient microulceration of the bladder mucosa noted at 3 hours, with rapid resolution.
- Pseudomonas aeruginosa cultured from 50% of kidneys at 1 week, with a decreasing infection rate over 4 weeks.
Conclusions:
- Pseudomonas aeruginosa causes acute, self-limiting bladder pathology.
- The urinary tract is susceptible to P. aeruginosa infection, with potential for kidney involvement.
- Understanding the temporal dynamics of infection aids in developing treatment strategies.
