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Anti-hypertriglyceridaemic activity of some phenylethylamine anorectic compounds
International Journal of Obesity
|January 1, 1980
Summary
Fenfluramine and amphetamine reduce circulating triglycerides in rats by affecting lipid absorption and potentially targeting key enzymes. These drugs show promise for anti-obesity effects.
Area of Science:
- Pharmacology
- Biochemistry
- Physiology
Background:
- Obesity is a significant health concern.
- Understanding the mechanisms of appetite suppressants is crucial.
Purpose of the Study:
- To investigate the effects of fenfluramine and amphetamine on lipid metabolism in rats.
- To explore the role of these drugs in lipid absorption and triglyceride reduction.
Main Methods:
- Administered fenfluramine and amphetamine to fed and food-deprived rats.
- Measured plasma triglyceride and cholesterol concentrations.
- Assessed lipid absorption using radiolabeled glycerol trioleate.
Main Results:
- Both drugs induced a hypotriglyceridaemic effect.
- Lipid absorption was inhibited by fenfluramine and amphetamine.
- The palmitoyl-CoA monooleinacyltransferase enzyme was identified as a potential target.
Conclusions:
- Fenfluramine and amphetamine acutely reduce circulating triglycerides.
- These effects are partly mediated by inhibiting lipid absorption.
- Fenfluramine's anti-obesity action may involve the palmitoyl-CoA monooleinacyltransferase enzyme.