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Related Experiment Videos

Human lymph node morphology as a function of age and site

P Luscieti, T Hubschmid, H Cottier

    Journal of Clinical Pathology
    |May 1, 1980
    PubMed
    Summary

    Lymph node morphology varies significantly with age and anatomical location. Germinal center formation decreases with age, while lipomatous atrophy affects peripheral nodes, impacting functional interpretation.

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    Area of Science:

    • Immunology
    • Histology
    • Anatomical Pathology

    Background:

    • Lymph nodes are crucial for immune responses.
    • Understanding lymph node morphology is vital for interpreting immune function.
    • Age and anatomical site are known factors influencing tissue structure.

    Purpose of the Study:

    • To histologically and morphometrically analyze lymph node structure across various ages and anatomical sites.
    • To quantify the distribution of cortical, paracortical, and medullary areas.
    • To assess germinal center formation and its relationship with age and location.

    Main Methods:

    • Histological examination of cervical, axillary, cubital, inguinal, popliteal, and mesenteric lymph nodes.
    • Morphometric analysis of lymph node cross-sections.
    • Quantification of germinal center number and surface area.

    Main Results:

    • Significant age-related and regional differences in lymph node morphology were observed.
    • Germinal center formation was most prominent in infants and children, decreasing with age.
    • Mesenteric and cervical lymph nodes showed more germinal centers, indicating higher antigenic stimulation.
    • Paracortical and medullary areas showed a gradual age-related reduction.
    • Peripheral nodes (cubital, axillary, popliteal) exhibited lipomatous atrophy.

    Conclusions:

    • Lymph node morphology is influenced by both chronological age and anatomical location.
    • Interpreting lymph node function requires consideration of these age-related and regional variations.
    • These findings provide a baseline for understanding normal lymph node changes throughout life.

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