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Related Experiment Video

Updated: May 11, 2026

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

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Sickle cell retinopathy

S J Graham, S A Gartner

Journal of the American Optometric Association

|June 1, 1980

Summary

This summary is machine-generated.

Sickle cell disease affects 10% of North American Black individuals, with SC and SThal types causing severe eye issues. Early detection and treatment of these sickle cell retinopathy forms can preserve vision.

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Area of Science:

Ophthalmology
Hematology
Genetics

Background:

Sickle cell disease (SCD) impacts 10% of North American Black individuals.
Four main forms exist: sickle cell trait (AS), SThal, SS, and SC disease.
SC and SThal SCD present with the most severe ocular manifestations, including proliferative and non-proliferative retinopathies.

Purpose of the Study:

To familiarize readers with the retinal signs of sickle cell disease.
To discuss the transmissibility and pathophysiology of high-incidence SCD.
To highlight the importance of early recognition and referral for prolonged visual function.

Main Methods:

Literature review and synthesis of existing research on sickle cell disease and ocular complications.
Analysis of prevalence data for different SCD forms in North American Black populations.
Overview of diagnostic criteria and therapeutic approaches for sickle cell retinopathy.

Main Results:

Approximately 1% of the Black population is at risk for serious ocular complications from SCD.
SC and SThal SCD forms are most frequently associated with severe retinopathy.
Early recognition and appropriate therapy can lead to prolonged visual function.

Conclusions:

Sickle cell disease, particularly SC and SThal forms, poses a significant risk for severe ocular complications like retinopathy.
Prompt diagnosis and management are crucial for preserving vision in affected individuals.
Understanding the pathophysiology and retinal signs is key for effective patient care.