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Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
06:59

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test

Published on: November 13, 2016

Glucose tolerance in the heavy-for-date neonate: a pilot study

A T Shennan, G Russell, H W Sutherland

    Journal of Perinatal Medicine
    |January 1, 1980
    PubMed

    Insights

    Infants with high birth weights showed abnormal glucose tolerance, with faster glucose disappearance rates. This enhanced glucose tolerance was linked to infant obesity, but posed no immediate clinical risk.

    Area of Science:

    • Pediatric Endocrinology
    • Metabolic Research
    • Neonatal Studies

    Background:

    • Large for gestational age infants are at increased risk for metabolic complications.
    • Understanding glucose metabolism in high birth weight neonates is crucial for early intervention.

    Purpose of the Study:

    • To investigate glucose metabolism in infants with birth weights above the 95th percentile.
    • To determine the correlation between glucose tolerance, birth weight, and infant obesity.

    Main Methods:

    • Intravenous glucose tolerance tests (IVGTT) were conducted on 12 infants.
    • Glucose disappearance rate (kt) was calculated and analyzed.
    • Correlations with birth weight and infant obesity were assessed.

    Main Results:

    • Four infants exhibited an abnormally high glucose disappearance rate (kt > 2.05).
    • No significant correlation was found between glucose tolerance and birth weight.
    • A significant positive correlation was observed between enhanced glucose tolerance and infant obesity.

    Conclusions:

    • Infants with high birth weight can display abnormal glucose metabolism.
    • Obesity in these infants is associated with enhanced glucose tolerance.
    • Current biochemical abnormalities do not appear to present a clinical hazard.

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