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High-pressure liquid chromatographic assay for chloramphenicol, chloramphenicol-3-monosuccinate, and
Journal of Pharmaceutical Sciences
|August 1, 1980
Abstract:
A high-pressure liquid chromatographic method for the sensitive and rapid determination of chloramphenicol, chloramphenicol-3-monosuccinate, and chloramphenicol-1-monosuccinate is presented. The procedure utilizes a reversed-phase chromatographic column with UV absorption detection. The assay is useful for monitoring patients receiving chloramphenicol, determining the pharmacokinetics of parenteral chloramphenicol sodium succinate, and certifying sterile chloramphenicol sodium succinate.