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Updated: Aug 7, 2026

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
09:04

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products

Published on: September 9, 2016

Decomposition of aminophylline in suppository formulations

J F Brower, E C Juenge, D P Page

    Journal of Pharmaceutical Sciences
    |August 1, 1980
    PubMed
    Summary

    Aminophylline suppositories degrade over time, losing ethylenediamine and forming insoluble amides. This reaction with fatty acids in the suppository base impacts product quality and stability.

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