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Poloxamer 188 as vehicle for injectable diazepam

A V Prancan, B Ecanow, R J Bernardoni

Journal of Pharmaceutical Sciences

|August 1, 1980

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Poloxamer 188 significantly reduced thrombophlebitis and vein necrosis in rabbits when used as a vehicle for diazepam. This suggests poloxamer 188 can mitigate diazepam

Area of Science:

Pharmacology
Drug Delivery Systems
Vascular Biology

Background:

Intravenous diazepam administration is associated with thrombophlebitis.
Diazepam crystallization and precipitation in blood/IV fluids cause this side effect.

Purpose of the Study:

To investigate if poloxamer 188 reduces thrombotic and inflammatory effects of diazepam.
To assess the solubilizing capability of poloxamer 188 for intravenous diazepam.

Main Methods:

Rabbits were used as a model to evaluate diazepam-induced thrombophlebitis.
Comparison of ear vein necrosis incidence between diazepam alone and diazepam with poloxamer 188.
Assessment of thrombosis and vessel integrity in treated ears.

Main Results:

Related Experiment Videos

Diazepam treatment resulted in a 72% incidence of ear vein necrosis.
Poloxamer 188 as a diazepam vehicle reduced necrosis to 25%.
Thrombosis and vessel integrity loss were lower with diazepam plus poloxamer 188.

Conclusions:

Solubilizing diazepam with poloxamer 188 may decrease the incidence of thrombotic and inflammatory side effects.
Poloxamer 188 shows potential as a stabilizing agent for intravenous diazepam formulations.